IL-23–Mediated Psoriasis-Like Epidermal Hyperplasia Is Dependent on IL-17A
نویسندگان
چکیده
منابع مشابه
IL-23-mediated psoriasis-like epidermal hyperplasia is dependent on IL-17A.
IL-23 and Th17 cells producing IL-17A and IL-22 are found in excess in skin affected by psoriasis. Previous studies showed that IL-22, but not IL-17A, mediates psoriasis-like epidermal hyperplasia following recombinant murine (rm)IL-23 injections into skin. To further investigate the role of IL-17A, ears of mice were injected with rmIL-23. Investigators blinded to treatment conditions and mouse...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2010
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1001001